If I use Django (a Python web framework) as the server-side backend for a mobile app that works on both Android and iOS (built with Flutter, React Native, etc.), what problems or difficulties might I face?
Welcome @Suheb !
My first reaction to your question is “Problems or difficulties” as compared to what?
Django works very well as a server-side provider. The Django REST Framework may be the best-known of the tools available to support this.
From Django’s perspective, the front-end is irrelevant when you’re using Django to create an http api-only server. Django will receive requests and return responses. Django doesn’t care what is issuing those requests.